Additionally, PD or DLB-associated SNPs in notable GWAS loci, such as MAPT (rs62053943), LRRK2 (rs34637584), BIN1 (rs6733839) and APOE (rs769449)8,14 are not associated with RBD at this sample size, which had sufficient power (>80%) to detect the effect sizes seen in PD and DLB. This evidence concerns the gene APOE and Parkinson disease.