Microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) is a rare renal cancer subtype characterized by chromosomal translocations involving transcription factor E3 (TFE3) or EB (TFEB) (on chromosomal loci Xp11.2 and 6p21, respectively) genes fusions with various partners1. This evidence concerns the gene TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.