TFEB and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: Microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) is a rare renal cancer subtype characterized by chromosomal translocations involving transcription factor E3 (TFE3) or EB (TFEB) (on chromosomal loci Xp11.2 and 6p21, respectively) genes fusions with various partners1.