Moreover, proteins involved in autophagy, such as ATG4B, PIK3C3, HSPA8, PARK7, and ubiquitin, were also downregulated in tRCC tumors with 3p deletion (Supplementary Fig. 4i). This evidence concerns the gene HSPA8 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.