IRS2 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: In addition, we found the tumor suppressor genes TP53 (n = 3), BRCA1 (n = 3), TSC2 (n = 3), SETD2 (n = 3), KMT2D (n = 3), and oncogene IRS2 (n = 3) recurrently mutated in tRCC (Supplementary Data 2).