Moreover, proteins involved in autophagy, such as ATG4B, PIK3C3, HSPA8, PARK7, and ubiquitin, were also downregulated in tRCC tumors with 3p deletion (Supplementary Fig. 4i). The gene discussed is PIK3C3; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.