The PTPN12-TFE3, ZNF627-TFE3, U2AF2-TFE3 and EIF4A2-TFEB fusion types of tRCC were also observed (Supplementary Fig 1a, b). Here, U2AF2 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.