Impaired glutathione (GSH) synthesis-related enzymes (GSR, GSS, GCLC) in SBS6 tumors further reinforced the association of SBS6 with oxidative damage in tRCC (Fig. 3g). The gene discussed is GCLC; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.