Microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) is a rare renal cancer subtype characterized by chromosomal translocations involving transcription factor E3 (TFE3) or EB (TFEB) (on chromosomal loci Xp11.2 and 6p21, respectively) genes fusions with various partners1. The gene discussed is TFE3; the disease is renal carcinoma.