The OS results indicated that patients with BLCA (P = 0.001), LIHC (P = 7.4 × 10-5), and Sarcoma (SARC) (P = 0.00013) with high UBE4B expression exhibited a worse prognosis, while patients with Esophageal Carcinoma (ESCA) (P = 0.018), HNSC (P = 0.035), and KIRC (P = 6 × 10-6) exhibited an improved prognosis. The gene discussed is UBE4B; the disease is sarcoma.