The results suggested that UBE4B mRNA was overexpressed in Cholangiocarcinoma (CHOL), Head and Neck Squamous Cell Carcinoma (HNSC), Liver Hepatocellular Carcinoma (LIHC), Lung Adenocarcinoma (LUAD), and Lung Squamous Cell Carcinoma (LUSC) using the TIMER database and downregulated in Breast Invasive Carcinoma (BRCA), Kidney Chromophobe (KICH), Kidney Renal Clear Cell Carcinoma (KIRC), Kidney Renal Papillary Cell Carcinoma (KIRP), Thyroid Carcinoma (THCA), and Uterine Corpus Endometrial Carcinoma (UCEC) (Figure 1A). This evidence concerns the gene UBE4B and cholangiocarcinoma.