The expression and prognosis of the upstream lncRNA of hsa-miR-22-3p, as a negative precursor molecule for miRNA, was analyzed using the starBase database, and five related lncRNAs (MIR4435-2HG, FGD5-AS1, LINC00858, SNAI3-AS1, and SNHG16) were shown to be significantly upregulated in HCC and associated with poor prognosis in patients with HCC. The gene discussed is SNHG16; the disease is hepatocellular carcinoma.