That said, some changepoint regions contain genes that may play a role in tumorigenesis such as Lymph-CLL changepoint regions encompassing CBL proto-oncogene B and NRP2 [24,25], and a changepoint region shared by Lung-SCC and Bladder-TCC which encompasses the DDX17 gene [26]. Here, NRP2 is linked to B-cell chronic lymphocytic leukemia.