All serum IFN-α concentrations measured with the Simoa pan-IFN-α assay were higher than those in the CSF in j-NPSLE patients, except for one patient who had also a diagnosis of AGS by homozygous mutation c.529G > A, p.Ala177Thr in RNASEH2B (Fig. 2B). Here, IFNA1 is linked to Aicardi-Goutieres syndrome.