MAP3K7 and frontometaphyseal dysplasia: In particular, heterozygous variants in MAP3K7, encoding TAK1, and its major interactor TAB2, cause cardio-spondylocarpofacial syndrome (Goff et al. 2016), cardio-faciocutaneousarticular syndrome (Micale et al. 1928) and fronto-metaphyseal dysplasia (Wade et al. 2016).