ENPP2 and Hepatic fibrosis: As a first step, family physicians or general practitioners at medical check-ups examine liver fibrosis–related markers (FIB-4, NFS, platelet count, enhanced liver fibrosis [ELF] test, Mac-2 binding protein glycosylation isomer [M2BPGi], autotaxin [ATX], type 4 collagen 7S [T4C7S], hyaluronic acid [HA], etc.