In addition, in NECA‐treated mice, we predict the high adenosine concentration at Day 1 potentially promotes adenosine‐dependent activation of A2A, A2B, and A3 adenosine receptors over the high‐affinity A1 receptor to promote tissue regeneration and restrain MPO accumulation and metaplasia in acute pancreatitis.44, 55. Here, MPO is linked to acute pancreatitis.