To confirm that adenosine generation promoted neutrophil‐mediated tissue injury, we modified the caerulein‐induced acute pancreatitis model by treating CD73−/− mice with a Ly6G neutrophil depletion antibody or vehicle (Figure 6A) and euthanized the mice at Day 4 post last caerulein injection. This evidence concerns the gene NT5E and acute pancreatitis.