In this context, we aimed to investigate the association of regional EPVS, that is, CSO‐EPVS and BG‐EPVS, with in vivo cerebral Aβ and tau deposition measured by PET in older adults with a diverse cognitive spectrum including CN and cognitively impaired (CI) individuals (i.e., MCI and Alzheimer's disease dementia). The gene discussed is MAPT; the disease is Alzheimer disease.