Given that p53 can regulate collagen expression by influencing cardiac fibroblast senescence (Zhu et al., 2013), and p53/Smad3 axis is the new target for renal fibrosis therapy (Overstreet et al., 2014), we further explored the potential role of p53/Smad3 in atrial fibrosis senescence and fibrosis‐related protein expression. The gene discussed is SMAD3; the disease is renal fibrosis.