STING1 and Nail dystrophy: SAVI is another type I interferonopathy with skin and lungs involvement, produced by monogenic STING gain—of—function mutation, with skin involvement ranging from mild chilblain vasculopathy to digital amputations, nasal septum perforation, livedo reticularis, facial rash, periungual erythema, onychodystrophy [52, 53].