SLE patients with high IFN activity will have increase titre of anti—double stranded DNA (dsDNA) antibody (ab), anti-Sjogren'syndrome-related antigen A (SSA) and anti-ribonucleoprotein (RNP) ab, highlighting the connection of IFN with B-cell maturation and autoantibody production [43]. Here, RNPC3 is linked to systemic lupus erythematosus.