Whereas the rs6265 SNP has received the most attention of those reported in the gene BDNF, others are associated with modest hippocampal or whole-brain atrophy, cognitive dysfunction and with potential pharmacogenetic effects on dopamine replacement strategies for PD as well, including the rs908867, rs11030094, rs10501087, rs1157659, and rs1491850 SNPs (11, 14–16). This evidence concerns the gene BDNF and Brain atrophy.