Despite significant measurable motor improvements the two PARK2+ patients experienced worsening of QoL at last follow-up mainly because of still intermittently occurring severe OFF dystonia and worsening in the QoL subdivisions “activities of daily living,” “social support,” and “communication.” One of them (see Supplementary Figure 1; yellow line), moreover, experienced significant worsening of apathy after DBS and a 75% reduction of levodopa. Here, PRKN is linked to Dystonia.