Interestingly, IL-6 receptor levels have been reported to reflect OSA severity (Zheng et al., 2018); FOS, FOSB, and JUN have been demonstrated to be involved in obesity, osteoporosis, and colorectal cancer (Skrypnik et al., 2017); and DUSP1 is upregulated in CIH in OSA patients (Hoffmann et al., 2013). Here, DUSP1 is linked to obesity due to melanocortin 4 receptor deficiency.