FHIT and myalgic encephalomeyelitis/chronic fatigue syndrome: The FRA3B site, the most common CFS site in lymphocytes, has a paucity of replication origins within the core of the region (Palakodeti et al., 2010), yet this disparity does not exist in fibroblasts, where the density of initiation events is comparable to that of the rest of the genome (Letessier et al., 2011).