ULK4 and myeloid sarcoma: Interestingly, Unc-51 Like Kinase 4 (ULK4), one of the selected protein coding transcripts in the reduced model has been proposed as a key regulator of myelination (Liu et al., 2018b) with ULK4 deficiency linked with disrupted white matter integrity (Lang et al., 2014), again a disease hallmark of MS.