AR expression or dihydrotestosterone (DHT) treatment can decrease the forkhead box O1 (FOXO1) expression and cause FOXO1 phosphorylation through the protein kinase B signaling pathway, which works as a tumor suppressor to BLCA cells metastasis, migration, invasion, and proliferation (Ide et al., 2020). The gene discussed is AKT1; the disease is bladder transitional cell carcinoma.