In addition, androgens have a high affinity to prostate tissue through the androgen receptors (AR), which can significantly influence the physiological state of prostate tissues and facilitate BPH development (Heinlein and Chang, 2004; Tong and Zhou, 2020), and trigger the occurrence of various bladder carcinomas (Wang et al., 2020a; Martinez-Rojo et al., 2021). This evidence concerns the gene AR and benign prostatic hyperplasia.