Immunohistochemistry analysis of 499 PC surgical specimens showed higher levels of cytoplasmic (not nuclear) of GSK3B protein, in addition to its correlation with aggressive clinicopathological parameters such as late clinical stage, lymph node metastasis, extracapsular extension, and a high Gleason score, as well as a 2-fold reduction in recurrence-free survival with up to 12-years follow-up (Li et al., 2009). The gene discussed is GSK3B; the disease is pachyonychia congenita.