The GEPIA results of all the 9 hub genes, have showed that expression levels of ABHD2, DCAF7, and GSK3B were upregulated, FGF2, NACC2, and NR3C1 were downregulated in prostate adenocarcinomas (PRAD) than the normal prostate tissues by more than 1.5 folds (p < 0.01), reinforcing our understanding that these genes have important role in carcinogenesis (Figure 5). This evidence concerns the gene NACC2 and prostate adenocarcinoma.