For example, circular RNA (circRNA) ciRS-7 in Alzheimer’s disease (AD) targets the trafficking of miRNA-7 and promotes overexpression of the ubiquitin-conjugating enzyme (UBE2A) defective in the expression of epidermal growth factor receptors (EGFR), thereby affecting the pathology of AD (Lukiw et al.). The gene discussed is UBE2A; the disease is early-onset autosomal dominant Alzheimer disease.