The observation that mesothelioma cells express pluripotent cell enhancers is consistent with our previous data where we had used a lentiviral fluorescence-based reporter construct sensing high SOX2 and OCT4 levels to identify and isolate a subpopulation of mesothelioma cells with cancer stem cell properties, characterized by chemoresistance and a higher tumor-initiating capacity in orthotopic xenograft and allograft mouse models.42 This evidence concerns the gene SOX2 and cancer.