As shown in Fig. 3, depletion of Lrrc8a or Lrrc8d significantly lowered the tumor response to carboplatin and resulted in a decreased overall survival (OS; P = 0.002 for Lrrc8a, P = 0.0131 for Lrrc8d; Fig. 3). The gene discussed is LRRC8D; the disease is neoplasm.