Wild‐type RUNX1 is required for the development of CBF‐AML, including t (8;21)/RUNX1‐RUNX1T1 and inv [16]/CBFB‐MYH11 leukaemia, which suggests a delicate balance between wild RUNX1 and RUNX1‐fusion protein contributes to leukaemia cell survival [14]. Here, CBFB is linked to acute myeloid leukemia.