A 32‐year‐old male with a history of well‐controlled HIV infection (with a normal CD4(+) T‐cell count [501 × 106/L; reference range 495–1635 × 106/L]) presented with acute new‐onset skin lesions (scattered umbilicated papules near mouth and base of bilateral groin area), sore throat, fever, myalgias, and tonsillar/genital ulcerations, with known recent exposure to monkeypox virus. Here, CD4 is linked to HIV infectious disease.