OSM, MCP‐2, TGF‐α, and CXCL6 are likely to have an association with endothelial dysfunction and some are mostly or additionally involved in IR (MCP‐1, FGF‐21, TRAIL, and ADA) or insulin metabolism (TNFSF14/LIGHT). The gene discussed is TNFSF10; the disease is endothelial dysfunction.