Our study showed that elevatedkynurenic acid concentrations were associated with PE en PPROM, which could havedetrimental neurodevelopment effects on the offspring.83, , , , , -89 Thus, future studies shouldinclude longitudinal assessment of KP metabolites throughout (un)complicatedpregnancies, and investigate the relation between KP metabolites in maternal andfetal blood. Here, NPPA is linked to preterm premature rupture of the membranes.