Several studies have demonstrated the predictive value of Il-6 and CRP for OF, PN, IPN, and mortality (Teerenhovi and Nordback, 1988; Ueda et al., 1997; Mándi et al., 2000; Kaya et al., 2007; Cardoso et al., 2013; Khanna et al., 2013; Karpavicius et al., 2016; Kolber et al., 2018; Vasudevan et al., 2018). This evidence concerns the gene CRP and bile duct papillary neoplasm.