They include molecules enabling the parasites to penetrate the tick midgut perithrophic membrane and invade epithelial cells (e.g. TROSPA), molecules involved in regulating Babesia infection (defensins and antimicrobial peptides – longicin, microplusin, longipain, LRR-domain and Kunitz-type protease inhibitors, Bm86, subolesin), invasion of other tick organs such as ovaries (calreticulin, glutamine synthetase, Kunitz-type serine protease inhibitors, vitellogenin receptor) and salivary glands (calreticulin, TROSPA). Here, CALR is linked to babesiosis.