Endothelial dysfunction is not only characterized by reduced NO bioavailability and another important fact is the increased expression of NOX1, NOX2 and NOX5, associated with inflammation, and reduced production of vasculature-protective biomolecules, such as the product catalyzed by NOX4 (Drummond and Sobey, 2014; Liao et al., 2018; Zhang et al., 2020). This evidence concerns the gene NOX4 and endothelial dysfunction.