NOX4 and endothelial dysfunction: NOX1, NOX2 and NOX5 are characterized by their direct involvement in the onset of inflammation, apoptosis and endothelial dysfunction, while NOX4, by contrast, is characterized as an important vasoprotective agent, involved in the suppression of cell death pathways and increased NO bioviability (Liao et al., 2018; Zhang et al., 2020).