For instance, bioactive chemerin is detected in serum and tissue fluids of patients suffering from diseases with musculoskeletal manifestations such as rheumatoid arthritis or osteoarthritis (Zhao et al., 2018; Carrión et al., 2019; Cajas Santana et al., 2021; Gonzalez-Ponce et al., 2021). This evidence concerns the gene RARRES2 and osteoarthritis.