A small molecule with the chemical structure 2-(anaphthoyl) ethyltrimethylammonium iodide (α-NETA), shown to inhibit CMKLR1, can suppress CNS autoimmune inflammatory disease and has been suggested as a novel approach to prevent or treat multiple sclerosis; a disease that is associated with loss of muscle mass and function (Kennedy and Davenport, 2018; Kumar et al., 2019). Here, CMKLR1 is linked to multiple sclerosis.