Interestingly, many disorders with chronic low-grade inflammation such as cardiovascular disease, cancer, alimentary tract disorders, metabolic syndrome, rheumatoid arthritis and osteoarthritis feature elevated levels of the adipokine chemerin (Stojek, 2017; Zhao et al., 2018; Carrión et al., 2019; Treeck et al., 2019). Here, RARRES2 is linked to metabolic syndrome.