CASR and colitis: In the attempt to assess the therapeutic applicability of the calcimimetics for the treatment of IBDs, Elajnaf et al. administered by gavage either two positive allosteric CaSR modulators, cinacalcet and a newly synthetized not absorbable calcimimetic, GSK3004744 (Sparks et al., 2017), or calcilytic NPS2143, to DSS-treated mice, which were used as a preclinical model of colitis.