The CaSR is therefore a key player in immune cell activation and, as such, it seems to contribute to the pathophysiology of many inflammatory diseases, including myocardial infarction (Liu et al., 2015; Zeng et al., 2018), sepsis (Wu et al., 2015b; Wu et al., 2015a), rheumatoid arthritis (Jäger et al., 2020), and orchitis (Su et al., 2020). This evidence concerns the gene CASR and rheumatoid arthritis.