CASR and colorectal cancer: Moreover, Iamartino et al. (2020) and Schepelmann et al. (2021) used colorectal cancer cell lines over-expressing the CaSR compared to not transduced cells (Mine and Zhang, 2015a; Mine and Zhang, 2015b; Zhang et al., 2015; Liu et al., 2018), where, in particular in the Caco2 and HT29 cell lines, the endogenous CaSR expression is reduced or even undetectable.