CASR and Alzheimer disease: Due to its direct involvement in neuroinflammation and AD dysfunction, the CaSR has been thought to behave as a danger-sensing/pattern recognition receptor in AD pathogenesis (Chiarini et al., 2020b) and, thus, it is thought to be a promising molecular target for AD treatment by using existing calcilytics (Chiarini et al., 2016; Dal Prà et al., 2019; Chiarini et al., 2020b).