CASR and colorectal cancer: Using two colorectal cancer cell lines over-expressing the CaSR fused to the green fluorescent protein (GFP), HT29CaSR-GFP and Caco2CaSR-GFP cells, and comparing them with their corresponding negative controls (HT29GFP and Caco2GFP), they observed that only those expressing the CaSR and treated with the positive allosteric CaSR modulator, NPS R-568, had an increased expression of pro-inflammatory markers IL-8, IL-23α, IL-1α, CSF1, CCL20, COX2, and PDL1, and increased secretion of IL-8 (Iamartino et al., 2020).