AHR and asthma: Afterwards, the proof of a direct involvement of the CaSR in the pathophysiology of asthma came from a study by Yarova et al. (2015), who observed that CaSR was over-expressed in bronchial smooth muscle cells of asthmatics and that pharmacological inhibition of the CaSR, by administering the calcilytic NPS2143 through inhalation, could abrogate AHR and lung inflammation.