BPGM and obesity due to melanocortin 4 receptor deficiency: Several enzymes involved in glycolysis pathway (carbohydrate catabolic processs), such as phosphoglycerate kinase one and biphosphoglycerate mutase (BPGM) were upregulated in cells from subjects with obesity (Supplementary Table S1), whereas the pentose phosphate pathway (PP pathway) was downregulated (Figure 1C).