Proteomic data showed that many important proteins in the lipid biosynthetic pathway were downregulated in myotubes from donors with obesity including hydroxymethylglutaryl-CoA (HMG-CoA) synthase, 3-beta-hydroxysteroid-delta (Mengeste et al., 2021) isomerase (EBP) and corticosteroid 11-beta-dehydrogenase isozyme 1 (HSD11B1). The gene discussed is HSD11B1; the disease is obesity due to melanocortin 4 receptor deficiency.