BMAL1 and cancer: Compared with that in normal tongue epithelial tissues/human tongue keratinocytes, BMAL1 expression were decreased in tongue squamous cell carcinoma (TSCC) patients/SCC9, SCC25, CAL27 cancer cell line, meanwhile, the cancer cell line displayed defferent BMAL1 expression rhythmic pattern characterized by shorter cycle and weaker amplitude (Tang et al., 2017).