Of note, there was no difference between the GLU- and CD34-labeled areas/cells before and after diabetes (Figure 7A); however, compared with the control group (Figure 7B, C), the INS-positive localization areas decreased significantly and GLU-positive localization areas increased significantly in the diabetes model group (p < 0.0001), and CD34 was expressed in the distribution region of former islet β-cells in relative Control group. Here, INS is linked to diabetes mellitus.