To improve successful treatment outcomes in cases of tuberculosis caused by multidrug resistant strains, 68 countries started using the drug bedaquiline, and 42 countries started using the drug delamanid at year-end 2017 (54); however, both drugs are not available in Brazil (6), and the strains sequenced presently demonstrated the presence of atpE and ddn genes that can confer resistance to these two drugs, respectively. This evidence concerns the gene DDN and tuberculosis.