Future phenotypic analyses are needed to determine their real potential for resistance to other drugs, in addition to pyrazinamide resistance, as other mutations (rpsA, rpsL, gid, rpoB, katG, gyrB, gyrA, tlyA, embA, embB, embC, fgd, fbiB, and fbiC) were found in genes responsible for resistance to several antibiotics used in the treatment of tuberculosis in humans, similar to most brazilian M. tuberculosis var. The gene discussed is RPSA; the disease is tuberculosis.