ATP5F1E and tuberculosis: To improve successful treatment outcomes in cases of tuberculosis caused by multidrug resistant strains, 68 countries started using the drug bedaquiline, and 42 countries started using the drug delamanid at year-end 2017 (54); however, both drugs are not available in Brazil (6), and the strains sequenced presently demonstrated the presence of atpE and ddn genes that can confer resistance to these two drugs, respectively.