EGFR and head and neck squamous cell carcinoma: At this regard, FOSCC shares several biological properties with HNSCC such as over-expression of EGFR (10) and, in a subset of tumors, association with PV infection, mainly by Felis catus PV type 2 (FcaPV-2), thus it is considered a reliable spontaneous animal model of human counterpart (11–13).