APP and Alzheimer disease: The same study reports the involvement of other natural anti-sense transcripts in the regulation of Amyloid-beta precursor protein (APP), which is associated with Alzheimer’s disease, and α-synuclein which is associated with Parkinson’s disease and Lewy body dementia (Spillantini et al., 1997; Jellinger, 2018; Hampel et al., 2021).