Furthermore, the expression of EZH2 decreased after administration of agomiR-124-3p in IBS-like rats (Figure 6E), whereas the expression of EZH2 increased after antagomiR-124-3p administration in controls (Figure 6F), indicating that miR-124-3p could inhibit EZH2 expression in the hippocampus. The gene discussed is EZH2; the disease is irritable bowel syndrome.