What is known—from experiments performed using felines—is that inner segments display morphological features characteristic of degeneration following retinal detachment, notably disorganisation, swelling, and a marked decrease in mitochondrial cytochrome C oxidase (COX IV) expression (Anderson et al., 1983; Mervin et al., 1999; Lewis et al., 2002). Here, COX4I1 is linked to retinal detachment.