The classic activation cascade of microglia can promote the synthesis and secretion of a large number of inflammatory mediators including nitric oxide (NO), proinflammatory cytokines interleukin-1 (IL-1), IL-6, and tumor necrosis factor-α (TNF-α), leading to neuronal death and accelerating the pathological progress of neurodegenerative diseases [2, 3]. This evidence concerns the gene TNF and neurodegenerative disease.