Validated by the GEO dataset, EGFR, MAPK3, RELA, CCND1, ESR1, PTGS2, NR3C1, CYP3A4, and PTPN11 have significant differential expression and were considered to be the core targets of GGD for the treatment of CHD. The gene discussed is CYP3A4; the disease is coronary artery disorder.