Involved in cell proliferation, the transcriptional activator FOXM1 may have an impact on the expression of several cell cycle genes, including cyclin B1 and cyclin D. Numerous studies have revealed the association of elevated FOXM1 expression levels with a poor prognosis in patients with ovarian cancer [41], pancreatic and esophageal cancers [42], malignant rhabdoid tumors [41], and small-cell lung cancer [43]. The gene discussed is CCNB1; the disease is esophageal cancer.