Ferroptosis may expose tumor antigens, increasing the tumor microenvironment's immunogenicity and enhancing the effectiveness of immunotherapy [15–17].However, the JAK-STAT1 pathway is activated, and SLC7A11 and SLC3A2 expression are downregulated, which causes ferroptosis in tumor cells when interferon gamma is released by cytotoxic T cells [18]. Here, IFNG is linked to neoplasm.