Furthermore, immunohistochemical staining showed that Ki-67 levels in transplanted tumour tissue from the ANGPTL4-shRNA and ANGPTL4-shRNA + G groups were lower than those in the control + G group (both, p < 0.001), which suggests that ANGPTL4 promotes tumor proliferation in vivo (Figure 5(b)). This evidence concerns the gene MKI67 and neoplasm.