S100A8 and gastric cancer: However, the cytotoxin-related gene A (CagA) protein, an important pathogenic factor of Helicobacter pylori (H. pylori) [143], promotes the invasion and migration of GC cells by activating NLRP3 inflammasome, while the suppression of H. pylori-triggered inflammatory response and the depression of pyroptosis via the ROS/NLRP3/caspase-1/IL-1β pathway may suppress the progression of GC [144].