GSDME and neoplasm: It is reported that chemosensitivity is related to the pyroptosis which is connected with the expression of yes-associated protein (YAP) and GSDME, and the activation of YAP suppresses GSDME expression to enhance the chemoresistance in SCLC cells, while the inactivation of YAP in SCLC tumor cells switches cell death from apoptosis to pyroptosis [66].