The polyphyllin VI (PPVI), a chief saponin extracted from trillium tschonoskii maxim (TTM), induces caspase-1-dependent pyroptosis through the ROS/NF-κB/NLRP3/GSDMD signal axis and inhibits the progression of NSCLC [54]. This evidence concerns the gene GSDMD and non-small cell lung carcinoma.