In addition, PPVI promotes the accumulation of ROS and the cleavage of caspase-3, downregulates the B-celllymphoma-2 (Bcl-2) expression, upregulates the Bcl-2-associated X (Bax) and p53 expression, and arrests the cell cycle in G2/M; thus, apoptosis of NSCLC cells is triggered [73, 74]. This evidence concerns the gene TP53 and non-small cell lung carcinoma.