The patient was treated with an ultrasound-guided injection of 10e11 viral particles of Ad5/3-Cox2LD24, an engineered oncolytic adenovirus which acquired tumor tropism by the cyclo-oxygenase 2 (Cox2) promoter driving E1A gene and a 24-bp deletion in Rb binding site of E1A, into the primary tumor site near the left kidney, adjacent lymph nodes and intravenously. The gene discussed is RB1; the disease is neoplasm.