Therefore, the detection of TFE3 immunohistochemistry and ASPL-TFE3 fusion gene is important for the diagnosis of ASPS, while the gene detection of TFE3 alone has high sensitivity and low specificity, and can only be used for primary screening or diagnosis of ASPS with obvious pathological features (51). This evidence concerns the gene ASPSCR1 and alveolar soft part sarcoma.