Cheng et al. (2021) reported that the downregulated expression of THAP9-AS1 in esophageal squamous cell carcinoma (ESCC) confers a poor prognosis and suppresses the growth of ESCC xenograft tumors via the miR-133b/SOX4 pathway. However, at present, the underlying mechanism of CDKN2A-DT and GCC2-AS1 in HNSCC remains unknown, and there is no documentation for the genes AC091982.3 and AC010618.2. Here, the roles of the five CRLs for our signature establishment in diverse types of tumors are summarized in Supplementary Table S5. The gene discussed is GCC2; the disease is esophageal squamous cell carcinoma.