In macrophages, deficiency in Mst1/2 worsens cardiac dysfunction after myocardial infarction, as mice lacking Mst1/2 in their macrophages exhibited a marked increase in left ventricular end-diastolic and end-systolic volume and decrease in ejection fraction and fractional shortening (Liu et al., 2021). The gene discussed is MST1; the disease is myocardial infarction.