De Vrij et al. also mentioned human microglia exhibit high expression of membrane-type 1-matrix metalloproteinase (MT1-MMP) post-incubation with GB EVs, which supports tumor growth, denoting the tumor proliferation aspect of cancer-associated immune cells in addition to their immunoregulatory role (De Vrij et al., 2015). Here, MMP14 is linked to neoplasm.