Luong et al. (Luong et al., 2021) also determined that glioma-derived EVs perform several pro-tumorigenic functions in monocytes such as upregulated expression of suppressive cytokines, proteins, PD-L1 and lymphocyte antigen six complex (Ly6C), downregulation of proinflammatory cytokines, MHC II and costimulatory CD80 expression as well as the conversion of monocytes into suppressive cells involved in inhibition of activated CD4+ T cells (Luong et al., 2021). Here, CD4 is linked to glioma.