ARF6 and neoplasm: Several mechanisms have been determined to influence cargo selection in EVs, notably the ADP-ribosylation factor 6 (ARF-6)-Exportin-5 axis, where ARF6-GTP interacts with Exportin-5 to deliver miRNA into tumor microvesicles (MVs) in an ARF6-GTP dependent manner (Clancy et al., 2019).