Noteworthy, time series scRNA-seq analyses from several cancer cells have also demonstrated that different external signals—such as TGFβ, EGF, and TNF—are able to induce EMT by triggering divergent intracellular pathways, with peculiar timing and trajectories (Cook and Vanderhyden 2020; Deshmukh et al., 2021). This evidence concerns the gene TGFB1 and cancer.