CD44 and breast cancer: To this regards, using flow cytometry Grosse-Wilde et al. isolated a subpopulation of CD24+CD44+ breast cancer cells also characterized by the mixed expression of E/M genes (such as E-cadherin, Epcam, VIM and ZEB), thus demonstrating that CD24+CD44+ co-expression is an hallmark of the hybrid E/M phenotype (Grosse-Wilde et al., 2015).