CD274 and neoplasm: Moreover, the epithelial gatekeeper miR-200 was found to inhibit PD-L1 expression in E cells whereas ZEB directly induces its upregulation during pEMT along with CD47 (or IAP), a surface protein that promotes tumor associated macrophages (TAM) polarization to a M2-like tumor-promoting phenotype (L. Chen et al., 2014; Sahoo et al., 2021b).