GLUT4 is down regulated in adipocytes of patients with T2DM (W. T. Garvey et al., 1992), and this in turn is associated with systemic insulin resistance (Garvey et al., 1988; Abel et al., 2001; Kahn, 2018; Santoro et al., 2021). Here, SLC2A4 is linked to type 2 diabetes mellitus.